The Fertility Formula: Inflammation, Hormones & Hope with Dr. Natalie Crawford
Episode 135: The Fertility Formula: Inflammation, Hormones & Hope with Dr. Natalie Crawford
In this powerful episode of the Conscious Fertility Podcast, Dr. Lorne Brown welcomes renowned reproductive endocrinologist Dr. Natalie Crawford for a deeply informative conversation on fertility, inflammation, hormonal health, and the science behind optimizing egg and sperm quality. Dr. Crawford shares her personal journey through recurrent pregnancy loss, her evidence-based whole-body approach to fertility care, and the foundations of her upcoming book The Fertility Formula. Together, they break down how inflammation, lifestyle, stress, and metabolic health shape reproductive potential — and why fertility is not a mystery, but a formula you can influence.
Key Notes
- Inflammation is a major driver of poor egg and sperm quality, hormone imbalance, and implantation challenges — but it is modifiable.
- Cycle tracking matters: luteal phase length and symptoms can offer early clues about hormonal and metabolic health long before bloodwork changes.
- Egg quality is not only about age — metabolic and inflammatory factors significantly influence cellular function.
- Stress and cortisol imbalance contribute to insulin resistance and inflammation, directly affecting fertility in both men and women.
- Lifestyle choices — sleep, movement, nutrition, toxin exposure, and emotional health — are central pillars of the “fertility formula.”
Watch the video or choose to listen to the podcast below
TIMESTAMPS
01:29 – Introduction to Dr. Natalie Crawford
02:23 – Natalie’s Background & Training
04:24 – Personal Journey Through Pregnancy Loss
06:19 – Rethinking Fertility Research & Clinical Approach
09:06 – IVF, Egg Quality & Building Blocks of Fertility
10:38 – How Long to Prepare Before Trying to Conceive
12:22 – Navigating Age, Fertility Options & Advocacy
16:18 – Rising Infertility & The Need for Proactive Screening
19:04 – Luteal Phase Insights & Cycle Tracking as a Vital Sign
25:50 – Chronic Inflammation as a Root Cause
33:17 – How Inflammation Impacts Eggs, Sperm & Implantation
48:24 – Lifestyle, Stress, and the Fertility Formula
Subscribe and join us on your favourite platform.![]()
Spotify: https://ow.ly/OThh50PAByx
Apple: https://ow.ly/MlLq50PAByw
YouTube: https://ow.ly/28bR50SzjQR
Bio
Dr. Natalie Crawford
Natalie Crawford, is a MD who is board certified in both Obstetrics and Gynecology and Reproductive Endocrinology and Infertility and is co-founder of Fora Fertility, a boutique fertility practice in Austin, Texas. Dr. Crawford is CEO and co-founder of Pinnacle, a professional network for women in medicine. She completed her undergraduate at Auburn University obtaining a degree in Nutrition Science, Medical School at University of Texas Medical Branch, OBGYN Residency at University of Texas Southwestern, and REI Fellowship at University of North Carolina, concurrently obtaining a Master of Science in Clinical Research. Dr. Crawford is a digital health educator on social media, YouTube, and hosts the podcast “As a Woman: Fertility, Hormones and Beyond” with over 5 million downloads. Her debut book, “The Fertility Formula: Take Control of your Reproductive future”released by Penguin Random House April 2026 Unlike many physicians, Natalie has a whole body approach to medicine – fusing lifestyle and functional medicine with science backed facts to help people conceive and understand their bodies.
Where To Find Dr. Natalie Crawford
– Website: www.nataliecrawfordmd.com/
– Facebook: www.facebook.com/nataliecrawfordmd/
– As a Woman Podcast: www.youtube.com/@asawomanpodcast
– Instagram: www.instagram.com/nataliecrawfordmd
– Book: The Fertility Formula
How to connect to Lorne Brown online and in person (Vancouver, BC)
Acubalance.ca book virtual or in-person conscious work sessions with Dr. Lorne Brown
Conscious hacks and tools to optimize your fertility by Dr. Lorne Brown:
https://acubalance.ca/conscious-work/
Download a free copy of the Acubalance Fertility Diet & Recipes and a copy of the ebook 5 Ways to Maximize Your Chances of Getting Pregnant from Acubalance.ca
Connect with Lorne and the podcast on Instagram:
@acubalancewellnesscentre
@conscious_fertility_podcast
@lorne_brown_official
Join Dr. Lorne Brown, each week on the Conscious Fertility Podcast, to learn how to put the “mind” back into “mind-body”, to influence your body and autonomic nervous system, and turn on and off genes for health, longevity, and peak fertility.
Natalie Crawford
It is not just saying, I’m going to do this thing to try and get pregnant, but if you set yourself up to feel your best, live your best, be in your best health, you are going to have an easier time navigating the challenges that might be in front of you. Fertility and infertility can be one of those things, but absolutely. You said at the very beginning of the episode, you have to get so sick to be diagnosed with something. That is how the medical system is made. By the time these little cellular changes result in disease, it is often too late to be able to reverse the process. But before that happens, you can make a huge change in your own health and your hormonal health.
Lorne Brown
By listening to the Conscious Fertility Podcast, you agree to not use this podcast as medical advice to treat any medical condition in either yourself or others. Consult your own physician or healthcare provider for any medical issues that you may be having. This entire disclaimer also applies to any guests or contributors to the podcast. Welcome to Conscious Fertility, the show that listens to all of your fertility questions so that you can move from fear and suffering to peace of mind and joy. My name is Lorne Brown. I’m a doctor of traditional Chinese medicine and a clinical hypnotherapist. I’m on a mission to explore all the paths to peak fertility and joyful living. It’s time to learn how to be and receive so that you can create life on purpose.
I am literally figuratively very excited to have Dr. Natalie Crawford on the Conscious Fertility Podcast. Many of you know that I look for those that really have evidence informed basis to support you in growing your families. I really want that credibility factor when we talk about all the options available to you and Dr. Natalie Crawford is that individual. I want to share a little bit about her background. It is impressive and also so you can kind of relax into the information we’re going to discuss and share because you can trust it with confidence because of her background in training. So she is a medical doctor who’s board certified in both obstetrics and gynecology and reproduction, endocrinology and fertility. So she’s what some people call the IVF doc, although I’ll tell you that’s not her go-to thing all the time. She’s co-founder of Fora Fertility. That’s her boutique fertility practice in Austin, Texas.
Dr. Crawford is also the CEO and co-founder of Pinnacle, a professional network of women in medicine. So you can start to see she’s really big into education. She completed her undergraduate at Auburn University. That’s where she obtained a degree in nutrition and science. Holy crap. How many doctors learn nutrition science already? I’m falling in love with you, Natalie as we talk. She went to medical school at the University of Texas Medical Branch. As we mentioned. She’s an OBGYN. She did her residency at University of Texas Southwestern and she’s an REI. That’s the term for IVF doc where she did her fellowship at the University of North Carolina, go Tar Hills concurrently. At the same time obtaining a master of science and clinical research. Dr. Crawford is a digital health educator on social media and YouTube and also the host of the podcast, As a Woman, fertility hormones and beyond.
And she has over 5 million downloads and she has a book out. Finally, all the things that people get to see one-on-one and online, she’s put this down into a book and that takes a lot of effort and work. Her book is called The Fertility Formula. I love this because I’m a math guy, right? I used to be an accountant, so I like formulations for fertility formula, taking control of your reproductive future, and I want to let you know that that is being released in April, 2026. I pre-ordered it, so I think she’s got some free things she’s going to share with you if you pre-order it. If you’re listening to this and it’s April 20,26 and beyond, you can just go buy it. But if it’s before that, please do pre-order it if you haven’t already. So Natalie, unlike many physicians, you actually have a whole body approach. You infuse lifestyle and functional medicine, obviously bringing in science based facts to help people conceive and really get to learn about their bodies. You also have personal experience. There’s one thing to have the education, there’s one thing to have clinical experience. You have something that’s also unique. You were a patient basically reproductive health. Are you willing to share a little bit about your background and your story?
Natalie Crawford
Yeah, absolutely. And just thank you so much for having me here today. It’s a huge honor and I’m really excited for this conversation. I have the unique position to during my medical training, so during the end of my OBGYN residency and at the beginning of my infertility fellowship having multiple pregnancy losses and I was pretty standard as far as didn’t have any health problems before this was preventing pregnancy, figured I would stop my birth control pill, we’d get pregnant, was the biggest question in my life before that was when should we have kids trying to balance it in medical training? And when I started to have pregnancy loss after pregnancy loss, I really had a rude awakening about what it’s like to be a patient to go and to feel like there must be something wrong with you, but to have every doctor be very dismissive to say everything’s fine.
Just keep trying, just relax. I heard all the things that we know in the infertility community that my patients have heard, and I started to realize that despite having expertise in this field, I had so many questions about what I should be doing and what was normal. Was my luteal phase normal? Were there foods that I shouldn’t be eating? What about exercise and sleep? And my OBGYNs didn’t have the answers to those questions and in fellowship nobody did either. And that really spurred me to really approach how I was going to practice medicine differently both from a, I’ve been there and I tell every patient who’s going through a pregnancy loss, I’ve been in your shoes, it’s the worst thing. I don’t hide my story because it has changed my approach. I know what it feels like to feel isolated and to feel really alone to question your sense of self and identity, which is a huge piece of if you always thought you’d be a parent and suddenly this may not happen for you to have these questions about what does your future look like and for it to feel just like an out of control process.
But in fellowship, you read off my nice accolades. I did get a master’s in clinical research and most people in the REI fellowship, so it is three years. You do a year and a half of clinical work and a year and a half of research. And most everybody does IVF research or basic science research and that’s pretty standard. And I remember I was going through my losses at this time. We didn’t know what was going on and I went up to my fellowship director and said, I don’t want to do basic science research. I’ve done that in the past. I want to get answers to the questions I have, the questions our patients have. I want to do clinical projects. And they said, well, if you’re going to do that, you’ve got to get more expertise in it and get a master’s. And I said, sign me up because I want to be able to evaluate studies and see what’s good and what’s bad.
And all of my fellowship research centered around natural fertility and the luteal phase and ovarian reserve and environmental toxins and vitamin D levels and mental health and fertility and really thinking about what question do I have? My patients must have that question too and let’s go and try to answer it. And that’s why I always say, even though I do see IVF every day, I see patients with IVF and I try to help them get pregnant. This idea that you’re natural fertility and IVF care are siloed off once you’ve gotten to IVF. None of the holistic stuff, none of your lifestyle factors matter, I think is a huge disservice that our field has propagated because we know egg sperm, I can only work with the egg and sperm quality I get when it comes to the lab. That means I’ve got to do my very best at picking the right protocol for your situation.
But as patients, empowering them to know what’s happening in their body, know what questions to ask, be able to make decisions that are right for them, but also to control all the factors that do impact your egg and sperm health along the way so you can move with confidence knowing the decisions you’ve made are right for you and that you’re doing everything that you can. And certainly a lot of this ties back to getting a nutrition degree. I was always fascinated by it and then shocked by how little medicine emphasized the foods we put in our body and the state of our body as I went through my own training. And we are luckily seeing, I think a tide change in medicine, but it’s taken a really long time
Lorne Brown
And people like you are helping with that tie change. So thank you. So you did your fellowship, like you said, most people when they do their research will focus on the IVF research and you looked into natural fertility and I want to just unpack that part where you said you do I-V-F-I-V-F is a great tool, right? It helps lots of people get pregnant, but what I heard is you get to work with the building blocks, the sperm and the egg and the uterine cavity, and if they’re poor, then there’s a chance the outcome is going to be poor. And if the building blocks the egg and sperm quality are at their peak potential, there’s a better chance of IVF succeeding. Fibro.
Natalie Crawford
Absolutely. And if somebody’s listening, they’ve gone through IVF or they know friends who have, there’s so many rate limiting steps when it comes to how many eggs you have and your age and things that you cannot change along the way. But I’ve seen so many people get told, oh, you must just have bad egg quality yet there’s nothing to say. These are the things you should do about that or what we should do. And I wish more people would never hear that, that they could go into this knowing that they were bringing the best egg quality to the table. They can. But I also always say, if I could put myself out of business, that would be ideal. If I could help more people get pregnant without needing IVF, that’d be amazing. It’s never going to be everybody because there are things like you said, that IVF does that will always be the amazing part of the technology. People who have no fallopian tubes or damaged tubes, severe male factor genetic diseases. There are circumstances where IVF will always be needed, but by focusing on a whole body approach, you’re going to be able to walk that road a lot easier.
Lorne Brown
So you had your book available for pre-order like nine months before it was available. We all know what that means. Nine months, like you said, it’s not lost on your preconception. When people are looking to optimize their fertility, do they do it the two weeks before they’re going to try and conceive ovulation? Do they do it just before they start the I VFS cycle Or also is there science behind how much time you may want to give it? In an ideal world as preconception care to help you reach your peak fertility potential egg and sperm quality, what would you recommend timing wise?
Natalie Crawford
Hey, from the moment you’re hearing this is going to be the best because your eggs are inside your body your whole life, some of these processes take a while to change your cellular function. But on a physiologic level, if we want to be more minute about it, we’ll say for somebody from a sperm standpoint, the life cycle of a sperm is about three months, 72 days in creation, 18 days to kind of come out. So I like to see sperm changes three to six months of optimizing lifestyle before you want to get pregnant. When it comes to the egg, it appears that the lifespan of an egg getting chosen, we’ll say out of the vault where I like to envision all eggs being stored into being available to be chosen as a dominant follicle. That whole process is about 300 days, but the 60 days prior to that is probably when the egg is most susceptible to the world around it.
And I think that that’s helpful to hear too, that okay, well I did this bad, bad thing all these years, what’s the point of making the change now? And I always say the point is that when the egg becomes closer to the surface of the ovary, it is more susceptible to the world around you. So start now, make these changes, start tracking your cycle, listening to your own hormone clues, but it’s not too late to undo perhaps decisions that were less wise of us in our younger years. And I think that messaging gets lost a lot when we think about the fact that the egg is inside the body our whole life we get into the damage is done. There’s no need to focus on that and like to say, no, that’s actually not true. Focusing on it now is really important.
Lorne Brown
So how is your approach, and I know this is again a shout out to your book in the fertility formula, you lay this out, but some of us don’t have the book yet because at the time of the recording it’s not published. But what happens when somebody comes to you and they go, I’m 35, I heard at 35 I have advanced maternal age, or somebody’s at 43. Is it kind of like we’ll just do the I VF and we’ll hope for the best? Or is there, are they able to advocate and be proactive to increase their chances of conceiving naturally or through a RT like IVF?
Natalie Crawford
One of the key themes through the book is that every decision is individualized. So there’s no one circumstance that’s going to be right for everybody. Similarly, when you only hear one option, that’s usually not a good approach, but you can’t make an informed decision if you don’t have all the data. And a lot of times, especially in IVF Care, what has happened is people get to this place, they get told IVF is the only option. They don’t get explained what it is, what’s going on in their body, what they should be doing, and it feels even more overwhelming. So I make sure we get a great history, I’m always doing a deep dive into the root cause. Can we get to the bottom of what’s going on here? Does that impact what we are? But honestly, a lot of times it’s what are our family goals and what is our circumstance?
Because sometimes IVF is the right answer and IVF is not a failure. That doesn’t mean we don’t do other things along the way. I think to speak to you, in my perfect world, I would change the entire fertility industry. I understand it exists based on we screen people once they have failed, meaning you have to try to get pregnant. Say if you’re under age 35 for a year, then you get to come in and get checked up if you’re over age 35, at least six months. And I really wish this was not the approach, right? This was the initial approach when the rate of infertility was one out of eight or less thinking that not a lot of people are going to have this. So there’s no use in public health screening people if they weren’t going to have a problem. But we live in a different world today and the rate of infertility is increasing, the rate of male infertility is increasing.
And I wish we could approach more proactive screening so that people could go into their family planning journey with a more goal-oriented mindset. Instead of what I did, I ignored it and then suddenly it was like, oh, let’s get pregnant. What do we do now? And what does that mean? That means understanding if you have a partner semen analysis and because it can take three to six months to improve sperm quality. So why do that? Why not find that information out after you’ve been trying already for a year and then three to six months to try to make it better? Find that information out much earlier. Ovarian reserve. If you’re running out of eggs, it doesn’t mean you can’t get pregnant, but we do know you often have a longer time to pregnancy. You obviously are going to have a huge impact on your time to menopause, but also for the number of eggs we can get for IVF.
And depending on where you are, you might want to be more aggressive to get to this pregnancy based on that information. But also I say that’s your body giving us a big red flag that something is wrong. And then also thinking about learning to cycle track and understanding what cycle tracking is. Many people hear me say that and they think I’m marking day number one down on my app, so my cycle is fine. But truly when it comes to your menstrual cycle, understanding the difference in your follicular and luteal phase, understanding if your luteal phase is regular, I’m a huge luteal phase nerve because that’s what I did all my thesis work on is really understanding the luteal phase. And what we see is that changes in the luteal phase are the first sign of ovulatory dysfunction. You very well might still be having regular cycles, but the luteal phase is getting shorter.
So when that is starting to happen, if you’re just marking your day one, you’re not going to be aware of this. So it’s education. So the book is going through the basic formula too. So number one, it’s education. You have to learn these basic facts about your body. And this is what I wish everybody would do earlier, right before you want to get pregnant, you stop that contraception well in advance, you learn how to track your cycles, you get some preliminary testing done, it’s helping you say, what are the red flags? Warning signs within my own body? When should I go see a doctor? What could these be? What questions should I ask? And then thinking about how you craft a fertility treatment plan that’s not one size fits all. Oh, that’s just the way we do it at this practice. But really in line with what’s going on within your body and your goals and your circumstance so that you know that’s the right decision for you.
But regardless of any of those things, we know that a major player in infertility right now, as we said earlier, is egg and sperm quality. And a lot of what is harming us as infertility rates are increasing, sperm counts are decreasing. More women have low ovarian reserve, miscarriage rates are increasing. A lot of this is because we live in a really pro-inflammatory world. So just trying to say I’m going to avoid inflammation is part of the puzzle. But for many things we have to make a very purposeful change or choice to set up our life and our day to try to decrease inflammation. And what it does, I would say inflammation is going to come in and interfere with how your brain is going to interpret your other hormones. Therefore it interferes with hormone signaling. But egg quality when we talk about this is both the genetic normalcy of your eggs largely tied to your age, but also the metabolic health of your eggs.
And we know women over age 38 who have infertility have more abnormally shaped mitochondria than women who don’t have infertility. And we know that there’s more evidence of high inflammatory markers and women who have infertility, especially as they are getting older compared to their peers who don’t. So the idea that egg quality is just age is an oversimplification and I think that feels very overwhelming. If I was 43 and somebody said egg quality is just age, it feels like, well, there’s nothing I can do. And it’s a more empowering approach to be honest with people and say, you’re smart enough to understand this age is a piece of the puzzle. We can’t change it. We got to work with it. Secondarily though, the metabolic health, how your egg divides the first three days of embryo life are all determined on the egg. So how do we make that egg health better?
And a lot of that is within your control. And I find that that is empowering to people to say, can’t help that I’m 43, but let me know that I’m controlling these other factors. And that really switches the mindset to being, I’m going to be more proactive about this. And in the perfect world, we’d learn all those things in our twenties and set up our life to be in this way most of the time so that when we do stay up all night studying or go drink with our friends or have cake or do all these random things, your body is meant to handle an inflammatory load and go back to homeostasis. But when you’re chronically inflamed and it sees it all the time, that same piece of cake can send you over the edge because your body doesn’t have the reserves to handle that. And of course I’m simplifying this just to generalize to people, but I would say it’s not one choice that’s going to make it or break it for you, but really this mentality that the sum of the decisions matter. And that should allow you to really start looking at how you structure your day and your life and the choices you make and make ’em for your hormonal health, both now when you want to get pregnant and for your longevity as well.
Lorne Brown
Alright, you guys, I hope you got this set to speed one, not 1.3 or 1.4 and you’re not scrolling because Dr. Natalie just gave you so many pearls and we’re going to unpack some of that. Where have you been all my life? I’ve got to move to Austin, Texas. This is great. First of all, you think like a Chinese medicine doctor, treating the individual and looking at signs in the body as messengers because sometimes the lab tests that we have in orthodox conventional medicine for it to show up out of range, you’re sick already.
Natalie Crawford
You’re really sick
Lorne Brown
Right? And there are subtle signs that the body will tell you that the labs won’t, that there’s something out of balance. Even certain inflammatory markers won’t show up in the blood, but you can feel it and sense it in the body. So I got to share my little cartoon one day and REI like this, so tell me if you like this. This was at one of my integrated fertility symposiums that I chaired. One of the docs said that luteal phase defect went out in the eighties because in my clinic where Chinese medicine doctors are naturopaths, so we care if your luteal phase is under 12 days,
Natalie Crawford
A hundred percent I care too.
Lorne Brown
You agreed too. Okay. And we care if there’s a lot of spotting in your luteal phase. And they said we don’t care. Back then they weren’t using letrozole, it was just clomid. We can fix it with clomid. And here’s what I said to them. I go, this is why we care if the egg is inside the follicle and they are one yin yang together, and then at the time of ovulation there’s a separation, the egg goes into the tube and the follicle stays behind on the ovary becomes the corpus lutetium and it’s producing the progesterone If it does not have the stamina to produce progesterone to keep laine, so it’s low progesterone or short as in you have a short cycle theoretically, then that follicle, which is nourishing the egg for those 120 plus days leading up ovulation wasn’t optimal. So although I can’t check easily if there’s good egg quality because that would destroy the egg, it’s too invasive. I can look at body signs for example. Spotting a short luteal phase could give me a sense if that follicle is not at its optimal health, which makes me think then the egg may not have reached its peak fertility potential. Does that make sense to you the way I think of that?
Natalie Crawford
Well, I love it and I’m just over here happy because I always say the same thing. The follicle is the foundation for the corpus. So if you are not ovulating at the right time, which is a communication between the brain and the ovary and so many factors can come and interfere with this, you’re not going to have a good foundation to make progesterone. And I’m just going to love you so much because a lot of my colleagues will say, yes, luteal phase issues don’t matter X, Y, Z. And again, I did all my research in it. So I’m a strong believer in the luteal phase and its importance, but also they’ll just draw a blood progesterone level in the luteal phase and act like that is a good representation of the strength of the luteal phase. But when you did your little cartoon in your hand, pulsed because it makes progesterone and pulses from the luteal phase, that made my heart so happy because we know LH comes from the brain impulses stimulating the corpus luteum impulses and progesterone levels are going to fluctuate.
So back to the one single blood test, can’t always give you the answer looking at the clinical characteristics, when are you actually ovulating? When are you studying for your next period? Is that 11 days or less? That’s abnormal. And why getting to the why and just throwing progesterone on somebody in the luteal phase also, maybe it’s better than nothing, but you’re not addressing the root cause. You’re not helping get a better egg. So often in medicine we’re just looking at the one data point in front of us and even as patients, we look at the one data point and we want something to fix that data point and we don’t step back and say, but what is this telling us? Understanding how our body works and how do we work backwards to what is causing this? And in the ideal world, we want to fix it there because that’s what’s really going to help us.
Lorne Brown
And so now I want to talk about the inflammation aspect that you talked about and how this can interfere with the health of the egg and the sperm and implantation. From my preparation for our interview, when you shared that you had four miscarriages, I think in your research that you did, you started to, hopefully you’ll tie that in that you started realizing there’s inflammation. Some people actually will have an autoimmune condition, which we know there’s inflammation. Some of them will have autoimmune like meaning the labs say you don’t have it, but all your signs and symptoms say you do. And so when you were sharing, looking at the signs and symptoms of the body, take a good history, that history of are you sleeping, do you get high histamine, you’re always having reactions, sleep. And then the cycle. In Chinese medicine, a healthy cycle has minimal to no PMS minimal to no pain, no clotting. Average regularity is more important, but at least 26 days less than 35, those are the things for a healthy cycle. I want to highlight this because in Chinese medicine, somebody that has PMS or spotting or pain, we often are told by their doctor that’s normal. And normal means basically you’re being dismissed. Everybody normal means
Natalie Crawford
Or you’re average. But that doesn’t mean that it’s optimal or that it’s how it’s supposed to be.
Lorne Brown
That’s the key. Normal means a lot of people have it and you won’t die from it. We don’t need to send you to the hospital to get triaged. It doesn’t mean it’s healthy. So I’m talking about a healthy cycle. We want you to bleed between three and seven days, less than three days in Chinese medicine would be considered too short, more than seven days in Chinese medicine would be considered too long a couple thousand years ago how they define what would be a healthy cycle. And when we see any female that is still menstruating or in her reproductive years, we always look at her menstrual cycle. It gives us so much information about the health of the organism being the female in front of us. So I get the sense that you look at all the signs besides labs, you take a good history and I get curious about the patients, and this was your experience with your miscarriages. They were saying, were you called unexplained then at the beginning?
Natalie Crawford
Yeah. So okay, I’m going to try not to ramble. I want to fit everything in first. I agree completely and I tell patients the same thing. We’ll use autoimmune disease as a good example. You’re going to live in a state of chronic inflammation for a decade before your body’s sick enough to get antibody levels high enough for a doctor to be able to look at blood work and say you have X, Y, Z, because that’s how these blood cutoffs are meant. That doesn’t mean that nothing is wrong with you just because somebody says, oh, those things are normal. It really means that we have not given people the advocacy to say what should be optimal? What am I feeling? And that these signs are red flags that something more is going on. And a huge part is trying to educate women on knowing what optimal is so they can start to investigate these warning signs that your body gives you.
And very often, yes, the menstrual cycle is a great vital sign. Fertility itself is a health marker, meaning women who have infertility have a higher risk of having a heart attack, a stroke, diabetes, metabolic disease, even cancer and dying early. And that’s a very scary stat to blurt out here. And what I say is it’s not that infertility causes any of those things, but it’s a failure of the field to recognize that what might be contributing to infertility is setting women off on a different pathway that is contributing to these other things such as chronic inflammation, which is truly the heart of all disease.
Lorne Brown
I just got to add, and guys, you too, just so you know, same.
Natalie Crawford
Oh yes, yes, absolutely.
Lorne Brown
Same. You have, you’re the canary in the mind. If your sperm is not great, then you also are at risk of cardiovascular skin, mental, emotional. So it takes two to make it be. I just want to make, because we’re talking about the female, but I just want to remind the guys that it’s also a canary in the mind for you too, that if you’re having issues with your sperm quality, it’s also a sign that there’s other things going on.
Natalie Crawford
Absolutely. And the same thing we use, we often use hormones, so female centric nowadays, but men have hormones too. And everybody, your hormones control how your body works. And if your hormones aren’t working right, you’re set up on a pathway that is not going to be conducive with long-term health. Okay, for my story, yes. I started to say I’ve had so many pregnancy losses, I’m now in fellowship, I have to decide to do my own research project, get started on this natural fertility path and realize that I didn’t believe this narrative that everything was just fine and I just have bad luck. And when I started to research a variety of different things, I kept seeing in the literature inflammation, inflammation comes to short luteal phase inflammation when it comes to low ovarian reserve inflammation. But this was something that we didn’t really talk about unless it was on the disease process pathway.
So oh, in endometriosis there’s inflammation, but nobody was talking about it, although it’s speckled all through the literature and I really am a very nerdy so I started to geek out and say, well, how do you know if you have inflammation? Is it just blood tests and what symptoms might your body have? And I became my own in one experiment where I said, okay, and everybody says there’s nothing I can do. Everybody says at this point IVF is the next step. Well, I’m an IVF fellow, so I can’t do IVF right now because I’m the one doing it. So we’re going to have to wait until this time period in my own training where that’s its own issue. But anyways, I have to wait until this time period in my training where I can go through this. So what am I going to do in the interim? I’m going to start to try to decrease the inflammation within my own body and start paying attention to the clues that my body’s giving me and see if that will make any difference. So I started to modify my diet. If this made me feel a variety of chronic inflammation symptoms, if I felt bloated, fatigued, lower energy, harder time concentrating. The problem is especially, can
Lorne Brown
We repeat that again just because people are going to wait. Some of them are wanting to know what are some of the signs and symptoms that you have? Chronic systemic inflammation. I hear fatigue
Natalie Crawford
Fatigue, low energy, difficulty sleeping, feeling bloated, both gaining or losing weight, but more commonly gaining weight, mild headache, there’s any type of GI distress. There’s so many, and I have a whole brain fog . That was one of the worst ones. And just feeling like you’re not this right saying I don’t feel like myself. I feel like something is off. And we gaslight ourselves after we get gaslit so many times to be told, no, you’re fine. You start to think that is the new normal. But I think it’s very important to step back and say, I know how I feel when I’m at my best. A change from your normal or your best or your baseline, that’s one of the best things for me. And so these symptoms that do get dismissed, that is your body telling you something is wrong. And so in my own Natalie experiment, I started changing the foods that I was eating looking at. Does this cause me to have inflammation or not? I started really prioritizing sleep when I could and better sleep practices changing how I exercise.
I’m going to start changing how I’m treating my body and paying attention to the foods that I’m eating a lot, making a very whole food plant forward diet, cutting out processed foods. And for me personally, I cut out gluten at the time and started tracking my cycle and realized I had a short luteal phase and started cutting out these things and got better. And I ended up getting pregnant after making all of these changes before we ever needed to do IVF and carried that pregnancy and she’s my daughter. And then got pregnant quite quickly after I gave birth with her, with my son because we were still living in this same focus because I also felt so much better. I always say once you stop drinking or take these other things out and the inflammation goes down, you’re going to wake back up to yourself and say, wow, I really was feeling bad.
I didn’t even recognize it as bad as it was because I had to adjust to what I was given every day. And a decade later I was diagnosed with celiac disease, but at the time everything was fine, nothing was wrong. And again, I was in that, I call it the preclinical phase where your body’s giving you all the warning signs, recurrent pregnancy loss was mine, and yet I wasn’t sick enough to flag positive on certain antibodies or get to this diagnosis. Also, I wasn’t even told that was something that could happen, that autoimmune disease could cause recurrent pregnancy loss. We talk about that more now, but that really wasn’t on the standard list of things we were doing at the time. But this has inspired me to really dive hard into chronic inflammation, insulin resistance, thinking about how these hormonal changes within our body, how our gut health impacts our hormone health and really refocus how I frame this to both patients, but also the internet and anybody I can get ahold of.
Because regardless if you’re trying to get pregnant now or not having good hormonal health is essential to feeling your best. And all of these things I rattled off are choices that you make every day when it comes to if you’re going to exercise and what are you going to do and how much are you going to sleep and are you actively trying to combat stress with something because we live in a very stressful world, but that’s not how our bodies are meant to be. Our bodies are meant to have stress release because there’s a bear. So suddenly glucose gets freed from on my cells so I can run from the bear and then I would come back down to my baseline to that homeostasis or that balance, but instead I get stressed over an email or bad news and all my glucose gets freed up and I don’t run from the bear and I sit there and that propagates this insulin resistance and this inflammation. And very often patients will say, I don’t have diabetes, so I don’t need to worry about this insulin hormone you’re talking about. But we live in a world and modern life propagates and creates this inflammatory state within your body, and we have to have an active plan to fight against that if we want to be in our best health. And that reflects even down to a cellular level to egg and sperm quality.
Lorne Brown
I want to go even to a deeper dive on this chronic inflammation, how it impacts your fertility. I love to play with the term because there isn’t a medical term called inflammaging.
Natalie Crawford
Yes, I love it
Lorne Brown
Right. I love that term. And I often say inflammaging is chronic systemic inflammation that leads to accelerated biological aging because we don’t want to be biologically old when it comes to anything, especially fertility, which leads to degenerative diseases, premature degenerative diseases. And then I add premature fertility decline. Does that resonate with you? Accelerated biological aging that leads to degenerative diseases in fertility.
Natalie Crawford
I love that you tack on the and fertility decline because when I try to use this term often for patients who are currently focused on their family building, aging is off here, we’re not really that concerned about aging yet. And so it feels hard to get them to make the connection that when your body is aging at a more accelerated pace, the same thing is happening in your eggs or your sperm and impacting your ability to conceive. So yes, your definition resonates and I like it even more than the standard aging definition.
Lorne Brown
So then how do these metabolic factors and inflammation impact fertility? Does it interfere with some of our reproductive or sex hormones? Does it interfere with ovulation implantation? How is it?
Natalie Crawford
It’s all of the above through different mechanisms. So let’s break ’em down. First I have to say that inflammation, it is on the pathway to harm and it is what directly is harming things, but what causes inflammation, right? And I think we have to say what is causing it as a variety of different things. And sometimes it’s a diseased state, right? So there are diseases that cause inflammation that you have no control over having. But secondarily it could be things. Your gut is the first line of defense, their gut health and what we call a leaky gut or increased intestinal permeability is a part of the way the gut is trying to protect what you’re eating from your bloodstream. And if you have a less healthy gut, you’re going to have more inflammation both directly into your blood. But also if the things that you are eating are pro-inflammatory, it’s going to accelerate that process.
So we have part of this, just an example of how inflammation is happening in our body. On a cellular level, inflammation is interfering with multiple different processes and part of it through an insulin resistance pathway and part of it through actual inflammatory factors themselves. So let’s go through some of the different ones when it comes to the brain. So for both men and women inside your brain, you have the hypothalamus and the pituitary gland, and I always say the hypothalamus is the central control station. It is hearing the hormone signals from everywhere else, making a decision on what needs to happen and sending the signal to the pituitary gland to say, do this, do that. And then the pituitary gland will send off the appropriate hormone response By default, when there’s so many different players, we have a risk for miscommunication and inflammation directly interferes with the hypothalamic response to hormone signals. So that inflammation can come from different things. It can come from being overweight, fat cells make both estrogen, but also they increase inflammatory factors. It can come directly from insulin resistance itself. It can come from having endometriosis, but having high levels of inflammation, that’s static interference on the radio. So if the brain is trying to hear what’s going on, high inflammation, static interference, it’s going to have a harder time interpreting the signals.
Lorne Brown
I want to just emphasize that. So you have this hypothalamus, but two tear ovarian adrenal access and when they’re in harmony, you get some great things happening, but inflammation can create that static so it’s causing confusion and it’s not being heard properly. And then this just regulates what’s going on in the body just because you have inflammation, there’s static going on, so the body just can’t hear the signals properly. Thank you. I just wanted to emphasize that
Natalie Crawford
Exactly. I always use bad analogies. Let’s imagine the ovaries are a plane and the brain is literally air traffic control. If they’re static on the radio, it is going to be a lot harder for the pilots to hear what to do. It’s going to be a lot harder for air traffic control to give the appropriate signals. People often, both patients and doctors feel like this is an all or nothing pathway while you are ovulating. So it is fine, but the quality of that ovulation, the timing, the queuing is off because of this static interference. So your brain is hearing the estrogen signal from the follicle and sending off a premature LH surge because it has this interference. And so then you’re ovulating at an inappropriate time having a bad corpus luteum even though you’re having regular periods. So very often we say, well, you’re still having periods, so brain ovaries, they’re doing good.
And we have to step back and say there’s a level of dysfunction before the switch is totally turned off. And this is for men and women, right? When you make sperm as a man, you’re making testosterone as well. The testosterone is communicating back to the brain about how much LH and FSH needs to go out because sperm and testosterone are made together and interference can come in there and block that pathway, for lack of a better word. So on a direct level, high inflammatory markers, inflammation from a variety of different causes can cause your hormones to be, we’ll use the trigger word of unbalanced, but unbalanced means not proper communication because hormones are dynamic. They’re meant to see a level respond appropriately. And when that system is not working right, it is going to create a hormone imbalance that actually propagates the system to be even worse because we’ll say for women, estrogen is anti-inflammatory.
And so if you are not making enough estrogen because your ovulation is off, suddenly you’re going to have a harder time fighting against the inflammation and you’re going to create a more pro-inflammatory environment. So we get into a cycle pattern that becomes really, really hard to correct. So hormone imbalance, improper brain and ovary communication, brain adrenal gland as well, that becomes one huge area where inflammation is impacting our fertility and our hormone health across stages of our lifespan. We also see on a minute level when we go back to the cells, egg and sperm quality. My bad analogy here is if we imagine that your chromosomes inside your egg, your chromosomes are held in perfect position from the moment you’re born until when you ovulate. And so the older you are, the longer the kindergartners have been standing in line and the more likely somebody’s gotten out of line.
That’s how I explain age-related pl. I’ve asked ’em to stand here for 43 years. Somebody’s going to get out of line. And some of that you cannot fix even if you are your healthiest self. But if we view inflammation from genetic factors, we could say inflammation in the ovaries is like having puppies and candy. I’m increasing the odds people are getting out of line because I’m providing this distraction or this interference. And then we have what we talked about earlier is the true metabolic function of the egg in the sperm that when inflammation is coming in, it is shifting the cellular function. The ovaries themself can develop insulin resistance as well and change the hormones that they’re making. But even on this very minute, looking at your egg, looking at your sperm, you see a change in both the genetics. So you can worsen your biological age with chronic inflammation from a genetic standpoint, but you can also harm how the egg can function.
Its ability to divide, to accept a sperm to form an embryo. Normally chronic inflammation comes in and interferes with that process when you have a lot of reactive oxygen species, a lot of these inflammatory markers, the body has these protective mechanisms to think that inflammation is a state of not wellbeing, and is this a good time to get pregnant? And so I always explain some of these checks and balances are because the body sees the red signs, it sees the warning and says, I’m not sure we should get pregnant. And it starts to backtrack your ability to do so because the state of your body is not well, for lack of a better word, but then we see implantation as well. So we have egg and sperm quality, I guess functionality, hormone balance. But then we also see implantation, and this is probably an area that is extremely sensitive to inflammation, and it’s a fine balance because implantation of an embryo requires inflammation.
So your body, and if we think about it, that makes sense, this embryo is going to come in and eat away at some of the endometrium and invade and get a good latch with that maternal blood supply. So inflammatory factors are really important in allowing that to happen. And that’s why just saying we’re going to take this medicine and cut out all inflammation. That’s not the answer because you need a proper immune response to allow implantation to happen. But when things are inflamed, you’ve shifted your ability to have an immune response, and that can impact the ability of the embryo to come in and implant. And that’s why stepping backwards, so many patients just want this immune treatment on the backend. Well, if we think it’s inflammation, if we think something’s here, let’s do this high end manipulation of my immune system. And very few people actually need that. What most people actually need is working backwards to try to get their own immune system to function better and to reset this by decreasing chronic inflammation and how our body functions.
Lorne Brown
So stress, how you move, how you sleep, your diet and your environment, how much extra toxins you get, all these things can contribute to your inflammatory condition. So the only one you don’t have control over is how many birthdays you’ve had, everything else, because that also will contribute to inflammation. Everything else we have some agency over. Did I understand it correctly?
Natalie Crawford
Yes, a hundred percent. I call this your inflammatory burden. The amount of excess inflammation that we are exposed to is a modifiable factor in our health and our fertility. And I think it’s important you said this, and you know this of course, but for your audience to say, insulin’s another important hormone that we throw around with inflammation because insulin resistance is so predominant. But I think when we tell people what’s really happening, it helps them because there was a study coming out that in women without PCOS that looked at insulin resistance markers, those who had higher levels of insulin resistance had poor IVF outcomes. And so very often we silo this insulin conversation into PCOS or diabetes, and we think that it doesn’t apply to everybody else, but insulin’s that gatekeeper. It’s an important hormone to allow glucose or sugar to get from your bloodstream into your cells.
And it’s the fuel for your cells that your cells need to do all of their actions. And so what happens is if you have a high blood glucose level for a variety of reasons, the foods you eat, improper gut health, high stress levels, as we said, freeze glucose up. So it gets into your bloodstream. This insulin stops being able to do the job. The cell starts listening. It’s like if a salesman comes to your door every day, you’re going to stop answering the door and you need more insulin to allow the gate to open and the glucose to come in. So you need that salesman banging on the door. So this is what insulin resistance is, is the cells start saying, I’m sick of answering the door, I’m not going to. And it takes a higher response. Well, high insulin levels themselves and the blood do cause inflammation.
They also cause increased fat deposition. So you’re going to put weight in places of your visceral fat so your body can store it because your cells are being starved of glucose even though your blood level is high. And this changes how our hormones are made, obviously, but also on an ovarian level, high levels of insulin in your blood switches the ovarian production to more androgens, and that’s in people who have or do not have PCOS. So the reason why we say, okay, dietary change is because that’s a direct way that we get higher levels of glucose lowering your stress and sleep, absolutely, because stress is also freeing this glucose up when it comes to muscle. This one building and using skeletal muscle has the four transporter, which allows glucose to get from the bloodstream into the cell without needing insulin. So it’s an insulin independent mechanism. If we think that my cells are already getting a little resistant, we need to start lowering your blood glucose level.
A lot of this can be building muscle, maybe not, I hate the word fasting, but sometimes time restricted eating, having a good period where you’re not consuming food following the daylight hours is a generally good rule of thumb where your body’s using up some of that blood glucose. And what you’re starting to do is try to get your cells to switch and go back to being more responsive so that it can clear out insulin’s supposed to rise and fall and rise and fall. It is not supposed to be a chronically elevated situation, but that’s just highlighting how these things that might seem benign, like get more sleep. People say, it doesn’t matter. I don’t ever need sleep. I’m just somebody who needs five hours of sleep. That’s how I’m wired. But that’s not how your body is made. And maybe you can function during the day that way, but you’re then setting up your day to have more morning cortisol, baseline higher inflammation levels, baseline higher insulin resistance because you didn’t use up all that blood glucose overnight. And it’s going to be extremely hard to achieve good hormone balance, for lack of a better word, when you’re starting out each day in a deficit. So even though some of these changes seem maybe not based in science, they actually are very based in science. When you start thinking about how the cells work, how your body functions and communicates, and understanding how the sum of all these decisions adds up and can be either helpful or harmful to your own health and fertility,
Lorne Brown
And there’s that wear and tear. So you’re talking about the biology on a cellular level, you may not be aware of it as the organism, Natalie or the organism Lorne, but there has accelerated aging happening on a cellular level. And again, I love the wisdom of this medicine. I practiced Chinese medicine, check out this quote before the age of 35, you cheat disease after age 35 disease cheats you. So there it is. You’re not aware of this. All that stuff you’re doing is so they got it. Biology was happening. I’m doing this. I’m fine. I’m 21.
Natalie Crawford
It catches up with you. You pay the toll later.
Lorne Brown
So they said that this is also over a thousand years ago, before age 35, you cheat disease, meaning your body’s going to deal with it. It’s young, it can handle it, but don’t you worry when you’re trying to get pregnant at 40, you’ll be reminded of what you did when you’re in your 19, 2030s and when you’re 75 or 80, if you live that long, your body will let you know what you did earlier on. That’s why you want to start in the moment now to start doing these lifestyle changes to help slow down accelerated biological aging. And then sometimes you can reverse it.
Natalie Crawford
Absolutely. And I just want to say I just did a very extended women’s health session with an expert in menopause, osteoporosis, and athletic performance. And I was asked the five keys to trying to improve your own fertility and went through what we just said, stress, sleep, exercise, diet, toxin avoidance,
And those are all the exact same things they’re talking about to have best athletic performance, to decrease your risk of osteoporosis, to flourish and menopause and improve longevity. So it is not just say, I’m going to do this thing to try and get pregnant, but if you set yourself up to feel your best, live your best, be in your best health, you are going to have an easier time navigating the challenges that might be in front of you. Fertility and infertility can be one of those things, but absolutely. You said at the very beginning of the episode, you have to get so sick to be diagnosed with something. That is how the medical system is made. By the time these little cellular changes result in disease, it is often too late to be able to reverse the process. But before that happens, you can make a huge change in your own health and your hormonal health.
Lorne Brown
And that’s the Chinese medicine idea of an ounce of prevention is worth more than a pound of cure. And that’s why taking your pulse, looking at your tongue and asking you certain questions, comes up with a pattern diagnosis to let us know whether you’re going towards death or longevity. Exactly. So what I really loved when I was listening to something about your book is you say it, and again, I love your book title, the fertility formula. You said fertility’s not a mystery, it’s a formula, right? And so can we share a few things of what you do then to help people optimize their fertility in our clinic in Vancouver to Accu Balance, by the way, we have a free diet book that I wrote with my naturopathic doctor, which is an anti-inflammatory, low-glycemic index. So anybody can download that for free. All the diets, by the way. But the reason they all work is because they all have something in common. No processed food, no refined flour, no added sugar, get lots of veggies and fiber
Natalie Crawford
Up that fiber
Lorne Brown
Yeah. And then some say meat, some say no meat, some say carbs, some say no carbs. But what’s in common is they all pulled out the major inflammatory high insulin foods. So diet, lifestyle, acupuncture, you’re in Austin in Texas. I know there’s acupuncturists there. Is acupuncture something that you work with with your patients? Do they get to see acupuncturists?
Natalie Crawford
Absolutely. And I always want to be mindful when we talk about, especially patients in infertility and patients going through IVF, because I don’t want you to ever hear anything I say and feel like you have to spend more money or you have to do something else and let that add to the burden. That being said, acupuncture has so many holistic benefits when it comes to blood flow to inflammation, stress relief, and a variety of different things, how it can work. And I encourage my patients to try it to go find a practitioner, see what the experiences for a lot of people, especially high functioning, high performers who maybe are going through IVF, it’s very hard when I say you need to schedule 20 minutes a day to carve out your own health and try to decrease stress and improve blood flow. It’s just very hard to self-regulate that when you have a list of to-do items and sometimes having an appointment on the books, somebody to hold you accountable, A change in environment like you get when you go to acupuncture can for a lot of people more profoundly impact the anti-inflammatory lifestyle that we are trying to curate.
So I think it is a tool in the toolbox. Does everybody have to do it? No, but do I have some patients who it’s going to extremely benefit them? Yes. And so I always say it’s a great thing to try to see how it impacts your health and see how you feel if for whatever reason, if you paid for it, you don’t have to do it. If you don’t have it financially, you can’t do that. That’s also okay. So it’s not a prescription, everybody must do it, but more often than not patients find mince to benefit from it. And on a personal level, my cousin is a naturopath and every time I see him I’m like, Hey, can we do a session, Frank, because he got trained in acupuncture as well in Chinese medicine as part of his training. And I can speak personally of the benefits for me, but I have patients who sometimes say that it’s not the thing for them and I want to support that truly that the one thing throughout a lot of this is there’s some tenant and some rules about what we need to try to do. We need to try to decrease inflammation, learn to listen to our body signs and learn what should be optimal slash normal so that we can recognize when it’s not and know what questions to ask, but our own body signs and decreasing inflammation in our own world. We can give ideas about how this is going to help, but you’ve got to know how it’s impacting you on your own level and learn to listen and make those changes because we all are cellularly built a little bit different and we’re going to respond differently to different situations.
Lorne Brown
As we close, I want to hear your favorite supplements from top five but low level laser therapy, something because of its mechanism on inflammation I use in my practice. We’re one of the early adopters in North America at our clinic. We learned about it in Japan and Denmark and it has this incredible mechanism like you talked about the inflammation. I said not too little, not too much.
It downregulates the pro cytokines that we don’t want inflammatory, it upregulates the ones that we need. We’ve seen this in injuries when somebody has a back injury, acute injury, if you take an anti-inflammatory like NSAIDs, it shuts down all inflammation. So you may have no pain temporarily, but it shuts down the inflammation needed for healing. So you’re good now, but then you end up with chronic back pain. The low level laser therapy shut down the inflammation that causes all the pain and discomfort, but it does not shut down the inflammation needed for healing. So you get rid of the pain and you also continue to heal. And so on a cellular level, I love low level laser therapy because it’s not going to interfere with the ovulation implantation because we need inflammation to live. But it definitely downregulates the inflammation that causes the pain and swelling. So are you familiar with low level laser therapy? Just curious.
Natalie Crawford
I honestly am not and I just wrote it down to be the next thing that I’m going to research and look into because it sounds really promising or exciting about what it potentially could help
Lorne Brown
Supplements. What are your top supplements that are in general that you find that you’re recommending often to patients?
Natalie Crawford
Alright, well by definition a supplement is supposed to supplement your diet. In the perfect world, we would get lots of good nutrients from our diet and we would need less supplements. So I always tell somebody the goal should be less supplementation and more nutrients from diet, but I understand we meet people where they are and sometimes there’s a transitional period in that bean. I also want to say that there’s no one size fits all approach to supplementation. Meaning there are things I might recommend if you have PCOS or you have endometriosis that are going to be different than if you just say I’m an average listener. So if your doctor is telling you one thing, there might be a reason and you should always ask why they’re recommending that and understand that it needs to be a personalized approach.
Lorne Brown
I just want to add this is for educational purposes. Dr. Natalie’s not recommending you. I always like to say Dr. Natalie Crawford is a doctor, she’s just not your doctor.
Natalie Crawford
If you’re trying to get pregnant, we want you to have folic acid. It is important in cell division, but the only thing that’s proven to prevent neural tube defects, which is a birth defect of your baby and you can find folic acid in prenatal vitamins and this is why you hear people say take a prenatal vitamin. Outside of that, things that are important are omega fatty acids, I like vitamin D, I like magnesium. And when it comes to fertility, I like CoQ10. And so those would kind of go ahead.
Lorne Brown
Yeah, I have my little list in front of me. So I have one on there that you haven’t mentioned so far, so I’m going to ask you.
Natalie Crawford
Yeah, I was wondering if that was the one you’re going to choose.
Lorne Brown :
That’s my one. And I mean we have other ones. There’s inositol melatonin, there’s so many out there. n-acetyl-l-cysteine obviously if somebody has PCOS, endometriosis because the research will do it, but because we’re talking about inflammation and insulin resistance, I always think of n-acetyl-l-cysteine . It reminds me of the movie I saw years ago called my Big Fat Greek wedding where the grandpa did Windex on everything like had eczema, you had arthritis. So to me it helps the liver do detox, it helps regulate inflammation, it helps regulate the insulins if I take it myself, right, because on a cellular level it can help with regulating inflammation. I never stay on something eternity. I take breaks. But for that reason I like NAC because of its general mechanism.
Natalie Crawford
Yeah, I add NAC onto any suspected inflammatory circumstance. So your endo, your PCOS, your unexplained infertility to me is chronic inflammation. A lot of my infertility patients end up being on it even if I don’t have it in my regular average person who may or may not have infertility. But I think it’s a very powerful tool and I think we’re going to see the adoption of NAC more like we have coq10. 10 years ago I was telling people to say, take coq10. And colleagues were saying, oh, they don’t need that. They don’t need that. And now that’s a pretty standard recommendation for fertility patients.
Lorne Brown
As we close, we’re talking about inflammation. I’ve been in practice since 2000 and so I used to really focus on that diet in the environment for the inflammatory invasion in the body because our podcast was called Conscious Fertility And beyond the mind body connection for me, that stress, which you talked about when you feel stressed and your body doesn’t feel safe, you start to release cortisol and all these stress hormones over time that can lead inflammation even though there’s no survival benefit that you got an email. What’s your take on stress and inflammation? To me, it was one of those things that I realized was one of the major factors because I may see somebody once or twice a week, but they have this negative dialogue going on. They’re on social media. Oh my God, everybody, I call it a fake book. Everybody has a great life but me. So how important is feeling safe in your body? How important is mental, emotional health when it comes to oxidative stress, inflammation and metabolic issues like insulin resistance?
Natalie Crawford
Hey, this is so important and this is wildly controversial in some ways because you’ll hear a lot of people say, I don’t want you to be stressed about being stressed. And they kind of discredit this one because they don’t want patients to blame, blame themselves. The reality is you have some stressors in your life that you cannot avoid, right? There are life circumstances, there’s political climates, there are things that happen in the world that are stressful, you have no agency over. And then there’s all the things during the day such as how you respond to things, how you structure your day, the support network you have, who you let into your life. And these things can work on a cellular level to benefit you. So cortisol release, normal biological response changes how your brain releases hormones, it’s pro-inflammatory, increases insulin resistance, all the things we talked about and just like on the inflammation scale, whereas acute inflammation good, you need a stress response to live.
Your body is wired this way. However, it is not meant to see chronic stress or to be stressed all the time. And in fact, if we think back evolutionary, the reasons you would encounter chronic stress were so bad that the body would shift away from reproductive functions because it would be, oh, are we in a famine? Is there a war? And your body goes into self-preservation mode. There’s no one size fits all remedy for stress. And I think that causes people to ignore this factor because they just want to know what do I need to do? But I always say we know what it feels like to get the release from cortisol, that feeling and that calm sense of self and presence. And you should, here’s what I recommend and I’d love to hear what you say every single day. The world is inflammatory and stressful and you need to carve out a protective time for you 20 minutes a day. How am I going to reduce cortisol?
And it’s not your phone, is it a walk outside, sitting outside, journaling, meditation, mindfulness, the acupuncture appointment, yoga, talking to your friend, going to therapy. There’s a variety of things that we could do. There’s not one magic thing that needs to be done, but you need to carve out time to seek that release and that cortisol reduction so your body can start to get more in the responsive state of I am not living like this every single moment of the day. And I have to say from a personal note, that state of mind when you’re in a situation that is stressful because infertility is stressful to say, this is happening to me and I have no control over it, it feels very hard. And having a mindset shift to this is the circumstance I’m in, but I’m going to take control of what I can. I’m going to ask the right questions and advocate for myself and change my lifestyle.
That’s empowering. And that mindset shift can contribute to how you manage and how you deal with stress as can community and support in people. And when I went through all my pregnancy losses, I didn’t share and I didn’t tell my friends I was pregnant and then I didn’t know how to call them and say, I was pregnant and didn’t tell you, and now I’m losing the pregnancy. And then I really didn’t know how to do that when I was pregnant two and three and let them in on what I had been dealing with. And this creates more isolation, this creates more stress. You feel like you’re living two different lives and even though you don’t have to share what is happening to you with the world or the internet, I encourage people to have somebody in their life who they do feel comfortable sharing this with. And it can be your friend. It doesn’t have to be your friend, it can be a work colleague, a therapist, your partner. There’s a variety of different people who this could be, but let somebody take some of the burden because there are people in your world who probably would show up for you if you give them the chance and they will take some of that stress and burden away. But you’ve got to open up the door of opportunity because people can’t show up if they don’t know what you’re going through.
Lorne Brown
We’re wrapping up here. I got to share. She’s got resources. I mean resources. She is an educator. I think this is why I was drawn to you. I like to educate. So Natalie just takes it to a whole other level, everybody. So first, check out her website because you’ll find so much Natalie Crawford md.com. It’s in the show notes. She offers courses, by the way, everybody, she’s got her YouTube channel, she has her podcast, she has her book, the Fertility Formula. If you’re listening to this before April of 2026, please pre-order it. If it’s already April, 2026, then you can order it and you are doing a promo two. If somebody pre-orders the book, what can they expect from you?
Natalie Crawford
Yeah, I know. The irony of a fertility book coming out and being available for pre-order nine months before you actually get it in print was not lost on me. And I told my publishers, we’ve got to do something a little more, especially because I’m talking about this information, but very often people want to take it to the next step. So if you pre-order the book and on the website you can put in your order information and there’s two different things that you’ll get access to immediately. One is what we’re calling the hormone reset. Essentially we went through how inflammation is so impactful, but these things that you can start doing now to start to reverse this, it’s a 30 page guide starting to walk you through it through those different five tenants we talked about. And then if you are in the position and maybe you’re doing IVF for that upcoming, you do get access to my IVF course, which is going to help you be a better advocate along the way. What are different protocols? What should I be asking? What do I expect? So that you can navigate that process with more education and from a place of knowledge.
Lorne Brown
Thank you very much, Natalie. This has been awesome. I so appreciate you.
Natalie Crawford
Thank you so much for having me. I’ve loved it.
Lorne Brown
Hi, Dr. Lorne Brown. I’m the host of the Conscious Fertility Podcast. And if you like this episode, we invite you to post comments like subscribe, because it’s our understanding it helps other people find this episode as well.
Speaker 4
If you’re looking for support to grow your family, contact Acubalance Wellness Center at Acubalance. They help you reach your peak fertility potential through their integrative approach using low level laser therapy, fertility, acupuncture, and naturopathic medicine. Download the Acubalance Fertility Diet and Dr. Brown’s video for mastering manifestation and clearing subconscious blocks. Go to Acubalance ca. That’s a-c-u-balance.ca.
Lorne Brown
Thank you so much for tuning into another episode of Conscious Fertility, the show that helps you receive life on purpose. Please take a moment to subscribe to the show and join the community of women and men on their path to peak fertility and choosing to live consciously on purpose. I would love to continue this conversation with you, so please direct message me on Instagram at Lorne_Brown_official. That’s Instagram, Lorne_Brown_official, or you can visit my websites Lornebrown.com and acubalance.ca. Until the next episode, stay curious and for a few moments, bring your awareness to your heart center and breathe.
